Search results for "Anti-Tubulin agents"

showing 2 items of 2 documents

[1,2]OXAZOLE DERIVATIVES: SYNTHESIS AND BIOLOGICAL EVALUATION AGAINST MULTIPLE MALIGNANT CELL TYPES

2021

LymphomaMedicinal ChemistryAnti-tubulin agentsSettore CHIM/08 - Chimica Farmaceutica
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Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity

2021

Abstract Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabetic and antidepressant properties. The presence of two heteroatoms, oxygen and nitrogen, offers possible interactions (hydrogen, hydrophobic, van der Waals or dipoles bonds) with a broad range of receptors and enzymes. Furthermore, the oxazole core conjugates low cytotoxicity with improved compound solubility and is well suited to structural modifications such as substitution with different groups and condensation to aromatic, heteroaroma…

chemistry.chemical_classificationColchicine binding inhibitorsbiologyChemistryAnti-Tubulin agentsHeteroatomRing (chemistry)Combinatorial chemistryRS1-441Other systems of medicinesymbols.namesakechemistry.chemical_compoundPharmacy and materia medicaEnzymeTubulinsymbolsbiology.proteinvan der Waals forceCytotoxicityOxazolesRZ201-999OxazoleConjugateCancer
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